Hospital Avicenne. Bobigny, France

Isoniazid-Induced Recurrent Pancreatitis

Sarah Mattioni, Michele Zamy, Frederic Mechai, Jean-Jacques Raynaud, Amelie Chabrol, Vanessa Aflalo, Michel Biour, Olivier Bouchaud

Abstract


Context Drug induced pancreatitis are rare but potentially serious. Thus, drug withdrawal is warranted. Case report A 79-year-old woman who was treated with antituberculosis therapy for 5 weeks was admitted to our unit for pancreatitis. Usual etiologies of pancreatitis were eliminated. Because of vomiting, antituberculosis therapy was withdrawn and symptoms disappeared. Eight days later, the same treatment was reintroduced and the patient presented recurrent pancreatitis; thus, treatment was withheld again followed by disappearance of clinical and biological abnormalities. Two days later, a treatment without isoniazid was reintroduced and no recurrence of symptoms was observed. Conclusions We have experienced a case of isoniazid induced pancreatitis. This is a rare cause of pancreatitis but potentially fatal thus recognition of drug induced pancreatitis and definitive withdrawal of the drug is required.

Keywords


Isoniazid /adverse effects; Pancreatitis; Tuberculosis

Full Text:

HTML PDF

References


Aouam K, Chaabane A, Loussaief C, Ben Romdhane F, Boughattas NA, Chakroun M. Adverse effects of antitubercular drugs: epidemiology, mechanisms, and patient management. Med Mal Infect 2007; 37: 253-61. [PMID: 17336011].

Nitsche CJ, Jamieson N, Lerch MM, Mayerle JV. Drug induced pancreatitis. Best Pract Res Clin Gastroenterol 2010; 24:143-55. [PMID: 20227028].

Izzedine H, Launay-Vacher V, Storme T, Deray G. Acute pancreatitis induced by isoniazid. Am J Gastroenterol 2001; 96: 3208-9. [PMID: 11721781].

Dickson I. Acute pancreatitis following administration of isonicotinic acid hydrazide; report of a case. Br J Tuberc Dis Chest. 1956; 50:277-8. [PMID:13342449].

Chow KM, Szeto CC, Leung CB, Li PK. Recurrent acute pancreatitis after isoniazid. Neth J Med. 2004; 62:172-4. [PMID: 15366703].

Chan KL, Chan HS, Lui SF, Lai KN. Recurrent acute pancreatitis induced by isoniazid. Tuber Lung Dis. 1994;75: 383-5. [PMID: 7531009].

Stephenson I, Wiselka MJ, Qualie MJ. Acute pancreatitis induced by isoniazid in the treatment of tuberculosis. Am J Gastroenterol. 2001;96: 2271-2. [PMID: 11467674].

Jin CF, Sable R. Isoniazid-induced acute hepatitis and acute pancreatitis in a patient during chemoprophylaxis. J Clin Gastroenterol. 2002; 35:100-1. [PMID: 12080238].

Sanchez AJ, Boken DJ. Isoniazid-associated pancreatitis. Infect Med. 2004;21: 622-23.

Rabassa AA, Trey G, Shukla U, Samo T, Anand BS. Isoniazid-induced acute pancreatitis. Ann Intern Med 1994;121:433-4. [PMID: 8053617].

Mendoza JL, Larrubia JR, Lana R, Espinos D, Diaz-Rubio M. Acute pancreatitis induced by isoniazid, a casual association. An Med Interna. 1998 15: 588-90. [PMID: 9882856].

Briongos-Figuero LS, Bachiller-Luque P, Pons-Renedo F, Eiros-Bouza JM. Isoniazid-induced acute pancreatitis. Enferm infecc Microbiol Clin. 2007; 25:217-8. [PMID: 17335704].

Pandey AS, Surana A. Isoniazid-induced recurrent acute pancreatitis. Trop Doc 2011; 41: 249-50.[21873403].

Feldman M, Friedman LS, Brandt LJ. Gastrointestinal and liver disease Pathophysiology, Diagnosis, Management. Ninth Edition ed: Sleisenger and Fordtran's; 2010.




DOI: http://dx.doi.org/10.6092%2F1590-8577%2F813

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.